Curriculum Vitae

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Postdoctoral Fellowship- September 2017- 2022

Department of Cell and Developmental Biology, University of Michigan (Ann Arbor, MI)

• Studied the role of host motor and nuclear membrane proteins in SV40 polyomavirus disassembly and nuclear entry

• Advisor- Billy Tsai, Ph.D.

Graduate Research- June 2012- August 2017

Department of Microbiology-Immunology, Northwestern University (Chicago, IL)

• Investigated the role of the Fanconi Anemia pathway and DNA damage response proteins in human papillomavirus (HPV) infection

• Spearheaded a retrospective clinical study in collaboration with the Department of Pathology at Northwestern University to examine the correlation between DNA repair protein levels and cervical neoplasia progression

• Advisor- Laimonis Laimins, Ph.D.

Undergraduate Research- October 2008- May 2011

Department of Microbiology and Molecular Genetics, Michigan State University (East Lansing, MI)

• Characterized the mouse polyomavirus Middle T antigen as a model for breast cancer progression

• Advisor- Michele Fluck, Ph.D.

PUBLICATIONS

Peer-Reviewed:

7. Spriggs CC, Cha G, Li J, Tsai B. 2022. Components of the LINC and NPC complexes coordinately target and translocate a virus into the nucleus to promote infection. PLoS Pathog. doi: 10.1371/journal.ppat.1010824.

6. Spriggs CC, Badieyan S, Verhey KJ, Cianfrocco MA, Tsai B. 2020. Golgi-associated BICD adaptors couple ER membrane penetration and disassembly of a viral cargo. J Cell Biol. doi:10.1083/jcb.201908099. PMCID: PMC7199864.

5. Spriggs CC*, Harwood MC*, Tsai B. 2019. How non-enveloped viruses hijack host machineries to cause infection. Adv Virus Res. 104:97-122. doi: 10.1016/bs.aivir.2019.05.002. PMCID: PMC6923802. (* co-first author; I wrote and helped to edit this book review chapter.)

4. Ravindran MS*, Spriggs CC*, Verhey K, Tsai B. 2018. Dynein engages and disassembles cytosol-localized SV40 to promote infection. J Virol. doi: 10.1128/JVI.00353-18. PMCID: PMC5974495. Selected as spotlight article. (* co-first author; I designed and performed experiments as well as helped to edit the manuscript.)

3. Spriggs CC, Blanco LZ, Maniar KP, Laimins LA. 2019. Expression of HPV-Induced DNA Damage Repair Factors Correlates with CIN Progression. Int J Gynecol Pathol. doi:10.1097. PMCID: PMC6295252.

2. Spriggs CC, Laimins LA. 2017. Human Papillomavirus and the DNA Damage Response: Exploiting Host Repair Pathways for Viral Replication. Viruses. doi:10.3390/v9080232. PMCID: PMC5580489.

1. Spriggs CC, Laimins LA. 2017. FANCD2 binds human papillomavirus genomes and associates with a distinct set of DNA repair proteins to regulate viral replication. mBio. doi: 10.1128/mBio.02340-16. PMCID: PMC5312087.

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Commentaries/Opinion Pieces:

7. Spriggs CC. Viruses unveil the mechanisms of nuclear entry. 2023. Nature Reviews Microbiology. doi: 10.1038/s41579-023-00940-z.

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6. Kushner DB, Cline TD, Danthi P, Debbink KM, Ferran MC, Flenniken M, Johnson DM, Mehle A, Morales DA, Mukhopadhyay S, Parker JSL, Spriggs CC, O’Donnell LA, Maginnis MS. 2022. Curriculum Guidelines for Graduate and Undergraduate Virology Courses. J Virol. doi:10.1128/jvi.01305-22.

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5. Spriggs CC, Pittman N, Scott NR, Taylor K, Kozik AJ. 2022. A talent network of Black microbiologists. Nat Microbiol. doi:10.1038/s41564-022-01085-0.

4. Termini CM, Rutaganira FUN, Palavicino-Maggio CB, Spriggs CC, Evans CS, McReynolds MR. 2021. Using virtual interviewing to create a more accessible hybrid academic job market. Cell. doi: 10.1016/j.cell.2021.11.027.

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3. Tsai B, Spriggs CC. 2021. Editorial Overview for the Special Section on Viral Entry. Curr Opin Virol. doi: 10.1016/j.coviro.2021.08.008.

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2. Spriggs CC. 2021. mSphere of Influence: Viruses- Pathogens or Expert Cell Biologists? mSphere. doi: 10.1128/ mSphere.00241-21. PMCID: PMC8546703.

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1. Taylor K, Kozik AJ, Spriggs CC, Scott N, Pittman N. 2021. Introducing the Black Microbiologists Association. Lancet Microbe. doi: 10.1016/S2666-5247(21)00038-0.

FUNDING AND AWARDS