Curriculum Vitae

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Postdoctoral Fellowship- September 2017- 2022

Department of Cell and Developmental Biology, University of Michigan (Ann Arbor, MI)

• Studied the role of host motor and nuclear membrane proteins in SV40 polyomavirus disassembly and nuclear entry

• Advisor- Billy Tsai, Ph.D.

Graduate Research- June 2012- August 2017

Department of Microbiology-Immunology, Northwestern University (Chicago, IL)

• Investigated the role of the Fanconi Anemia pathway and DNA damage response proteins in human papillomavirus (HPV) infection

• Spearheaded a retrospective clinical study in collaboration with the Department of Pathology at Northwestern University to examine the correlation between DNA repair protein levels and cervical neoplasia progression

• Advisor- Laimonis Laimins, Ph.D.

Undergraduate Research- October 2008- May 2011

Department of Microbiology and Molecular Genetics, Michigan State University (East Lansing, MI)

• Characterized the mouse polyomavirus Middle T antigen as a model for breast cancer progression

• Advisor- Michele Fluck, Ph.D.

PUBLICATIONS

* co-first author

1. Spriggs CC, Laimins LA. FANCD2 Binds Human Papillomavirus Genomes and Associates with a Distinct Set of DNA Repair Proteins to Regulate Viral Replication. mBio. 2017 Feb 14;8(1):e02340-16. doi: 10.1128/mBio.02340-16. PMID: 28196964; PMCID: PMC5312087.

2. Spriggs CC, Laimins LA. Human Papillomavirus and the DNA Damage Response: Exploiting Host Repair Pathways for Viral Replication. Viruses. 2017 Aug 18;9(8):232. doi: 10.3390/v9080232. PMID: 28820495; PMCID: PMC5580489.

3. Ravindran MS*, Spriggs CC*, Verhey KJ, Tsai B. Dynein Engages and Disassembles Cytosol-Localized Simian Virus 40 To Promote Infection. J Virol. 2018 May 29;92(12):e00353-18. doi: 10.1128/JVI.00353-18. PMID: 29593037; PMCID: PMC5974495 (.

4. Spriggs CC, Blanco LZ, Maniar KP, Laimins LA. Expression of HPV-induced DNA Damage Repair Factors Correlates with CIN Progression. Int J Gynecol Pathol. 2019 Jan;38(1):1-10. doi: 10.1097/PGP.0000000000000477. PMID: 29995652; PMCID: PMC6295252.

5. Spriggs CC*, Harwood MC*, Tsai B. How non-enveloped viruses hijack host machineries to cause infection. Adv Virus Res. 2019;104:97-122. doi: 10.1016/bs.aivir.2019.05.002. Epub 2019 Jul 2. PMID: 31439154; PMCID: PMC6923802.

6. Spriggs CC, Badieyan S, Verhey KJ, Cianfrocco MA, Tsai B. Golgi-associated BICD adaptors couple ER membrane penetration and disassembly of a viral cargo. J Cell Biol. 2020 May 4;219(5):e201908099. doi: 10.1083/jcb.201908099. PMID: 32259203; PMCID: PMC7199864.

7. Taylor K, Kozik AJ, Spriggs CC, Pittman N, Scott NR. Introducing the Black Microbiologists Association. Lancet Microbe. 2021 Apr;2(4):e131-e132. doi: 10.1016/S2666-5247(21)00038-0. Epub 2021 Feb 16. PMID: 35544186.

8. Spriggs CC. mSphere of Influence: Viruses-Pathogens or Expert Cell Biologists? mSphere. 2021 Mar 31;6(2):e00241-21. doi: 10.1128/mSphere.00241-21. PMID: 33789943; PMCID: PMC8546703.

9. Tsai B, Spriggs CC. Editorial overview. Curr Opin Virol. 2021 Oct;50:171-172. doi: 10.1016/j.coviro.2021.08.008. Epub 2021 Sep 8. PMID: 34507100.

10. Termini CM, Rutaganira FUN, Palavicino-Maggio CB, Spriggs CC, Evans CS, McReynolds MR. Using virtual interviewing to create a more accessible hybrid academic job market. Cell. 2021 Dec 22;184(26):6217-6221. doi: 10.1016/j.cell.2021.11.027. PMID: 34942095; PMCID: PMC9717443.

11. Spriggs CC, Pittman N, Scott NR, Taylor K, Kozik AJ. A talent network of Black microbiologists. Nat Microbiol. 2022 Apr;7(4):469. doi: 10.1038/s41564-022-01085-0. PMID: 35197603.

12. Spriggs CC, Cha G, Li J, Tsai B. Components of the LINC and NPC complexes coordinately target and translocate a virus into the nucleus to promote infection. PLoS Pathog. 2022 Sep 6;18(9):e1010824. doi: 10.1371/journal.ppat.1010824. PMID: 36067270; PMCID: PMC9481172.

13. Kushner DB, Cline TD, Danthi P, Debbink KM, Ferran MC, Flenniken M, Johnson DM, Mehle A, Morales DA, Mukhopadhyay S, Parker JSL, Spriggs CC, O'Donnell LA, Maginnis MS. Curriculum Guidelines for Graduate and Undergraduate Virology Courses. J Virol. 2022 Sep 28;96(18):e0130522. doi: 10.1128/jvi.01305-22. Epub 2022 Sep 12. PMID: 36094313; PMCID: PMC9517691.

14. Spriggs CC. Viruses unveil the mechanisms of nuclear entry. Nat Rev Microbiol. 2023 Oct;21(10):632. doi: 10.1038/s41579-023-00940-z. PMID: 37700053.

15. Adams C, Gonçalves AP, Warring S, Ettema TJG, Weyrich LS, Spriggs CC. Off the beaten track: Understudied microbes and their potential. Cell. 2024 Sep 19;187(19):5217-5219. doi: 10.1016/j.cell.2024.08.035. PMID: 39303687.

16. Wang K, Eady AN, Amaya I, Stanczak A, Spriggs CC. Temporal gating of nuclear import: How Merkel cell polyomavirus exploits the cell cycle for nuclear entry. PLoS Pathog. 2025 May 30;21(5):e1013217. doi: 10.1371/journal.ppat.1013217. PMID: 40445976; PMCID: PMC12157840.

17. Donovan-Banfield I, Pittman N, Kozik AJ, Taylor K, Spriggs CC, Davis E. Reclaiming microbiology: scientists as community members and advocacy leaders. Microb Genom. 2025 Oct;11(10). doi: 10.1099/mgen.0.001533. PMID: 41090203.

18. Amaya A, Spriggs CC. High-Resolution Imaging Techniques to Interrogate Virus-Host Interactions. mSphere. 2026 Feb 19:e0081625. doi: 10.1128/msphere.00816-25. PMID: 41711433.

FUNDING AND AWARDS