Research

The Spriggs Lab

at the University of Michigan

My lab studies the host-pathogen interactions required for successful virus infection. We are particularly interested in understanding the relationship between virus infection and cancer.

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Highlighted Publications

Complete List of Published Work in My Bibliography:

https://www.ncbi.nlm.nih.gov/myncbi/chelsey.spriggs.1/bibliography/public/

POLYOMAVIRUS NUCLEAR ENTRY

Spriggs CC, Cha G, Li J, Tsai B. 2022. Components of the LINC and NPC complexes coordinately target and translocate a virus into the nucleus to promote infection. PLoS Pathog. 18(9):e1010824. doi: 10.1371/journal.ppat.1010824. PMID: 36067270.

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DISASSEMBLY OF SV40 BY DYNEIN CARGO ADAPTORS

Spriggs CC, Badieyan S, Verhey KJ, Cianfrocco MA, Tsai B. 2020. Golgi-associated BICD adaptors couple ER membrane penetration and disassembly of a viral cargo. J Cell Biol. 219(5):e201908099. doi: 10.1083/jcb.201908099. PMID: 32259203.

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DNA DAMAGE RESPONSE PROTEIN EXPRESSION IN CIN PROGRESSION

Spriggs CC, Blanco LZ, Maniar KP, Laimins LA. 2019. Expression of HPV-Induced DNA Damage Repair Factors Correlates with CIN Progression. Int J Gynecol Pathol. 38(1):1-10. doi: 10.1097/PGP.0000000000000477. PMID: 29995652.

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FANCD2 IS AN IMPORTANT REGULATOR OF HPV REPLICATION

Spriggs CC, Laimins LA. 2017. FANCD2 binds human papillomavirus genomes and associates with a distinct set of DNA repair proteins to regulate viral replication. mBio. 8(1):e02340-16. doi: 10.1128/mBio.02340-16. PMID: 28196964.

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