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RESEARCH

Research: Education

Sept 2017- June 2022

POSTDOCTORAL RESEARCH

My postdoctoral research with Dr. Billy Tsai sought to elucidate the entry mechanisms of polyomavirus. My project focused on how SV40 hijacks host cellular motors and nuclear membrane proteins to reach the nucleus.

June 2012 - August 2017

GRADUATE RESEARCH

During my PhD, I worked with Dr. Laimonis Laimins in studying the role of the host DNA damage response in human papillomavirus (HPV) replication and transformation.

HIGHLIGHTED PUBLICATIONS

Complete List of Published Work in My Bibliography:

https://www.ncbi.nlm.nih.gov/myncbi/chelsey.spriggs.1/bibliography/public/

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POLYOMAVIRUS NUCLEAR ENTRY

Spriggs CC, Cha G, Li J, Tsai B. 2022. Components of the LINC and NPC complexes coordinately target and translocate a virus into the nucleus to promote infection. PLoS Pathog. 18(9):e1010824. doi: 10.1371/journal.ppat.1010824. PMID: 36067270.

DISASSEMBLY OF SV40 BY DYNEIN CARGO ADAPTORS

Spriggs CC, Badieyan S, Verhey KJ, Cianfrocco MA, Tsai B. 2020. Golgi-associated BICD adaptors couple ER membrane penetration and disassembly of a viral cargo. J Cell Biol. 219(5):e201908099. doi: 10.1083/jcb.201908099. PMID: 32259203.

DNA DAMAGE RESPONSE PROTEIN EXPRESSION IN CIN PROGRESSION

Spriggs CC, Blanco LZ, Maniar KP, Laimins LA. 2019. Expression of HPV-Induced DNA Damage Repair Factors Correlates with CIN Progression. Int J Gynecol Pathol. 38(1):1-10. doi: 10.1097/PGP.0000000000000477. PMID: 29995652.

FANCD2 IS AN IMPORTANT REGULATOR OF HPV REPLICATION

Spriggs CC, Laimins LA. 2017. FANCD2 binds human papillomavirus genomes and associates with a distinct set of DNA repair proteins to regulate viral replication. mBio. 8(1):e02340-16. doi: 10.1128/mBio.02340-16. PMID: 28196964.

Research: Projects
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