RESEARCH
Sept 2017- June 2022
POSTDOCTORAL RESEARCH
My postdoctoral research with Dr. Billy Tsai sought to elucidate the entry mechanisms of polyomavirus. My project focused on how SV40 hijacks host cellular motors and nuclear membrane proteins to reach the nucleus.
June 2012 - August 2017
GRADUATE RESEARCH
During my PhD, I worked with Dr. Laimonis Laimins in studying the role of the host DNA damage response in human papillomavirus (HPV) replication and transformation.
HIGHLIGHTED PUBLICATIONS
Complete List of Published Work in My Bibliography:
https://www.ncbi.nlm.nih.gov/myncbi/chelsey.spriggs.1/bibliography/public/
POLYOMAVIRUS NUCLEAR ENTRY
Spriggs CC, Cha G, Li J, Tsai B. 2022. Components of the LINC and NPC complexes coordinately target and translocate a virus into the nucleus to promote infection. PLoS Pathog. 18(9):e1010824. doi: 10.1371/journal.ppat.1010824. PMID: 36067270.
DISASSEMBLY OF SV40 BY DYNEIN CARGO ADAPTORS
Spriggs CC, Badieyan S, Verhey KJ, Cianfrocco MA, Tsai B. 2020. Golgi-associated BICD adaptors couple ER membrane penetration and disassembly of a viral cargo. J Cell Biol. 219(5):e201908099. doi: 10.1083/jcb.201908099. PMID: 32259203.
DNA DAMAGE RESPONSE PROTEIN EXPRESSION IN CIN PROGRESSION
Spriggs CC, Blanco LZ, Maniar KP, Laimins LA. 2019. Expression of HPV-Induced DNA Damage Repair Factors Correlates with CIN Progression. Int J Gynecol Pathol. 38(1):1-10. doi: 10.1097/PGP.0000000000000477. PMID: 29995652.
FANCD2 IS AN IMPORTANT REGULATOR OF HPV REPLICATION
Spriggs CC, Laimins LA. 2017. FANCD2 binds human papillomavirus genomes and associates with a distinct set of DNA repair proteins to regulate viral replication. mBio. 8(1):e02340-16. doi: 10.1128/mBio.02340-16. PMID: 28196964.