September 2017- Present
My current research seeks to understand how a DNA tumor virus, polyomavirus (PyV), transports to the cell's nucleus where it replicates. We are particularly interested in how PyV hijacks host cellular motors to reach its destination.
June 2012 - August 2017
During my PhD, I worked with Dr. Laimonis Laimins in studying the role of the host DNA damage response in human papillomavirus (HPV) replication and transformation.
DNA DAMAGE RESPONSE PROTEIN EXPRESSION IN CIN PROGRESSION
Spriggs CC, Blanco LZ, Maniar KP, Laimins LA. Expression of HPV-induced DNA Damage Repair Factors Correlates With CIN Progression. Int J Gynecol Pathol. 2019 Jan;38(1):1-10. doi: 10.1097/PGP.0000000000000477. PubMed PMID: 29995652; PubMed Central PMCID: PMC6295252.
DISASSEMBLY OF SV40 BY DYNEIN CARGO ADAPTORS
Spriggs CC, Badieyan S, Verhey KJ, Cianfrocco MA, Tsai B. Golgi-associated BICD adaptors couple ER membrane penetration and disassembly of a viral cargo. J Cell Biol. 2020 May 4;219(5). doi: 10.1083/jcb.201908099. PubMed PMID: 32259203; PubMed Central PMCID: PMC7199864.
FANCD2 IS AN IMPORTANT REGULATOR OF HPV REPLICATION
Spriggs CC, Laimins LA. FANCD2 Binds Human Papillomavirus Genomes and Associates with a Distinct Set of DNA Repair Proteins to Regulate Viral Replication. mBio. 2017 Feb 14;8(1). doi: 10.1128/mBio.02340-16. PubMed PMID: 28196964; PubMed Central PMCID: PMC5312087.