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RESEARCH

 

POSTDOCTORAL RESEARCH

September 2017- Present

My current research seeks to understand how a DNA tumor virus, polyomavirus (PyV), transports to the cell's nucleus where it replicates. We are particularly interested in how PyV hijacks host cellular motors to reach its destination.

GRADUATE RESEARCH

June 2012 - August 2017

During my PhD, I worked with Dr. Laimonis Laimins in studying the role of the host DNA damage response in human papillomavirus (HPV) replication and transformation.

HIGHLIGHTED PUBLICATIONS

Complete List of Published Work in My Bibliography:

https://www.ncbi.nlm.nih.gov/myncbi/chelsey.spriggs.1/bibliography/public/

 
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DNA DAMAGE RESPONSE PROTEIN EXPRESSION IN CIN PROGRESSION

Spriggs CC, Blanco LZ, Maniar KP, Laimins LA. Expression of HPV-induced DNA Damage Repair Factors Correlates With CIN Progression. Int J Gynecol Pathol. 2019 Jan;38(1):1-10. doi: 10.1097/PGP.0000000000000477. PubMed PMID: 29995652; PubMed Central PMCID: PMC6295252.

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DISASSEMBLY OF SV40 BY DYNEIN CARGO ADAPTORS

Spriggs CC, Badieyan S, Verhey KJ, Cianfrocco MA, Tsai B. Golgi-associated BICD adaptors couple ER membrane penetration and disassembly of a viral cargo. J Cell Biol. 2020 May 4;219(5). doi: 10.1083/jcb.201908099. PubMed PMID: 32259203; PubMed Central PMCID: PMC7199864.

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FANCD2 IS AN IMPORTANT REGULATOR OF HPV REPLICATION

Spriggs CC, Laimins LA. FANCD2 Binds Human Papillomavirus Genomes and Associates with a Distinct Set of DNA Repair Proteins to Regulate Viral Replication. mBio. 2017 Feb 14;8(1). doi: 10.1128/mBio.02340-16. PubMed PMID: 28196964; PubMed Central PMCID: PMC5312087.